Surrogate Endpoint Analysis: An Exercise in Extrapolation
نویسندگان
چکیده
منابع مشابه
Surrogate endpoint analysis: an exercise in extrapolation.
Surrogate endpoints offer the hope of smaller or shorter cancer trials. It is, however, important to realize they come at the cost of an unverifiable extrapolation that could lead to misleading conclusions. With cancer prevention, the focus is on hypothesis testing in small surrogate endpoint trials before deciding whether to proceed to a large prevention trial. However, it is not generally app...
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ژورنال
عنوان ژورنال: JNCI: Journal of the National Cancer Institute
سال: 2012
ISSN: 1460-2105,0027-8874
DOI: 10.1093/jnci/djs527